HOTAIR/miR1 axis acts as a potential chemotherapy target in gastric cancer

Gastric cancer is one of the most common cancers in world. Delayed diagnosis cause death patients. Long noncoding RNAs (lncRNAs) are a group non-coding that effective incidence cancers. Studies different determined HOTAIR as an important lncRNA tumorigenesis. In gastric cancer, function initiation and progression seems to be crucial. this study, we confirmed significant differential expression between tumors normal tissues datasets. following, regulatory its interaction with miRNAs development was analyzed. Our analysis upregulation essential pathways associated cancer. Further numerous potential targets for HOTAIR. Among them, demonstrated miR-1 miRNA negative correlation tumors. Validation target cisplatin chemotherapy drug. Eventually, effect on target, miR-1, checked by vitro study. Cisplatin treatment cell line showed there downregulation treated cells. conclusion, comprehensive silico experimental study provided evidence importance HOTAIR/miR-1 axis diagnostic strategies